In 2020, there were 37.7 million women with HIV, comprising approximately half of the global population with HIV.1 Women with HIV have a high burden of comorbidities, leading to AIDS-related illnesses being the leading cause of death globally among women of reproductive age.2 There is a well-recognized sexual dimorphism in people with HIV, and sex differences in HIV acquisition.3 There is a known association between sex and immune activation in