Approximately 30 years after the beginning of the HIV epidemic, emtricitabine–tenofovir disoproxil fumarate (FTC/TDF; Truvada, Gilead) was approved in 2012 as the first pre-exposure prophylaxis (PrEP) therapy. However, of the 1.2 million Americans eligible for PrEP, only an estimated 70,000 had an active prescription for PrEP as of the end of 2017.1 In 2019, FTC–tenofovir alafenamide (FTC/TAF; Descovy, Gilead) was approved as a second PrEP