By Laurie Fickman
Omadacycline (Nuzyra, Paratek) may help prevent Clostridioides difficile infections, which are responsible for nearly 500,000 infections annually in the United States (J Infect Dis 2023 Dec 5. doi:10.1093/infdis/jiad537).
Omadacycline had demonstrated a low likelihood of causing C. difficile in clinical trials, but no one understood why. In a small phase 1 human clinical trial, Kevin Garey, PharmD, MS, the Robert L. Boblitt Endowed Professor of Drug Discovery at the