JUNE 29, 2025

Disseminated Histoplasmosis, Hemophagocytosis Plagues 2 Patients With HIV in the ‘Histo Belt’

By Susan Kreimer
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Chinelo Animalu

Maintain a high degree of suspicion for histoplasmosis in the immunocompromised host, especially if they live in the “Histo Belt,” experts warned.

Disseminated histoplasmosis is an invasive fungal infection that may infect the immunocompromised, including those with HIV, in certain parts of the United States, most commonly the Ohio and Mississippi River valleys. In these “Histo Belt” geographic areas, soil and bat or bird droppings may