SEPTEMBER 9, 2022

Fatal Triazole-Resistant Aspergillus fumigatus Infection Linked to Environmental Fungicides

By Ethan Covey

A fatal case of fungicide-associated triazole-resistant Aspergillus fumigatus infection has been identified in Pennsylvania, according to a CDC report. The A. fumigatus organism contained a TR34/L98H genetic mutation that is linked to agricultural fungicide use. 

The patient was a 65-year-old immunocompromised man, who previously underwent chimeric antigen receptor T-cell therapy for acute myeloid leukemia (Emerg Infect Dis 2022;28[9]:1904-1905). One month before hospital