California has responded to the ongoing avian influenza (H5N1) outbreak by monitoring human and animal activities, testing wastewater and raw milk, and even testing for the virus in cats, said its public health laboratory director Anthony Tran, DrPH, MPH, D(ABMM). Speaking at the ASM Microbe 2025 meeting, in Los Angeles, Dr. Tran said this was the first time that a One Health approach to infectious disease management has been incorporated into a statewide emergency response.