JANUARY 5, 2022

Managing Post-Transplant Refractory/Resistant CMV

Older antivirals for these severely immunocompromised patients are associated with serious toxicities; New agents look like better options.

By Conni B. Koury

Cytomegalovirus (CMV) infection is the most common infectious complication in solid organ transplant and hematopoietic stem cell transplant (HSCT) recipients.

The incidence varies depending on the type of transplant, CMV serostatus of the donor and recipient, and the level of immunosuppression. Overall, about one-third of transplant patients will have CMV infection, which when left untreated, can progress to clinically severe and sometimes life-threatening disease. CMV infection