AUGUST 7, 2023

Can JAK Inhibitors Decrease HIV Viral Reservoirs?

By IDSE News Staff

Janus kinase (JAK) inhibitors, specifically ruxolitinib, may significantly decay the viral reservoir of people with HIV, offering a novel pathway toward long-term remission or cure, according to a presentation at the 2023 International AIDS Society (IAS) Conference in Brisbane, Australia.

The HIV viral reservoir, essentially a small number of immune cells containing dormant virus integrated into the genomes of individuals who have suppressed viral replication with HIV