SEPTEMBER 15, 2021

Ultrasensitive Testing Finds no Toxemia in Severe C. Difficile Infection

By David Wild

Originally published by our sister publication, Gastroenterology Endoscopy News

Ultrasensitive testing using the Single Molecular Assay (Simoa) did not find circulating serum Clostridioides difficile toxins in patients with fulminant C. difficile infection (CDI), a multicenter group has reported.

C. difficile toxin A (TcdA) and toxin B (TcdB) can cause systemic complications and extracolonic manifestations consistent with sepsis or toxemia in fulminant CDI, noted the investigators,