To treat the fungal infection disseminated histoplasmosis in patients with advanced AIDS, a single IV infusion of high-dose liposomal amphotericin B (L-AmB), followed by oral therapy with itraconazole, was found to be just as effective as daily IV infusions, but less toxic, according to a small phase 2 trial presented at IDWeek 2022, held in Washington, D.C. (abstract LB2303).
“Disseminated histoplasmosis is a major killer of persons living with AIDS in South and Central